• Rashid A., Schlüfter F., Holtmann C., Kunze C., Thaler K., Daumer M., Schlesinger S., Griewing B.: "Usage of Accelerometers in the Home Care for multiple sclerosis patients". To appear in GI-Edition - Lecture Notes in Informatics (LNI), 2008
• van Wieringen W., Kun D., Hampel R., Boulesteix A.-L.: "Survival prediction using gene expression data: a review and comparison." CSDA, accepted 2008
• Held U., Steyer K., Menzler S., Küchenhoff H., Daumer M.: "Evaluation of Some Alternative Designs for Phase II Multiple Sclerosis Trials - A Simulation Study." Drug Information Journal, in press
• Boulesteix A.-L., Porzelius C., and Daumer M.: "Microarray-based classification and clinical predictors: On combined classifiers and additional predictive value." Bioinformatics, online first, 2008
• Ebers G., Heigenhauser L., Daumer M., Lederer C. and Noseworthy J.: "Disability as an outcome in clinical trials." Neurology, online first, 2008
• Daumer M, Held U, Ickstadt K, Heinz M, Schach S, Ebers G: "Reducing the probability of false positive research findings by pre-publication validation - experience with a large multiple sclerosis database." BMC Medical Research Methodology 2008, 8:18
• Boulesteix A-L., Kondylis A., Krämer N.: "Invited comments on: Augmenting the bootstrap to analyze high dimensional genomic data." TEST 17, 1133-0686, 2008
• Schunkert H. et al. for the Cardiogenics Consortium: "Repeated Replication and a Prospective Meta-Analysis of the Association Between Chromosome 9p21.3 and Coronary Artery Disease" Circulation 117, 1675-1684, 2008
• Boulesteix A.-L., Strobl C., Augustin T., Daumer M.: "Evaluating microarray-based classifiers: an overview." Cancer Informatics 4: 77-97, 2008
• Garner SF, Jones CI, Stephens J, Burns P, Walton J, Bernard A, Angenent W, Ouwehand WH, Goodall AH; BLOODOMICS Consortium: "Apheresis donors and platelet function: inherent platelet responsiveness influences platelet quality." Transfusion. 2008 Jan 10; [Epub ahead of print]
• Jones CI, Garner SF, Angenent W, Bernard A, Berzuini C, Burns P, Farndale RW, Hogwood J, Rankin A, Stephens JC, Tom BD, Walton J, Dudbridge F, Ouwehand WH, Goodall AH; Bloodomics Consortium: "Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus." J Thromb Haemost. 5(8): 1756-1765, 2007
• Ouwehand WH; Bloodomics and Wellcome Trust Case Control Consortia: "Platelet genomics and the risk of atherothrombosis." J Thromb Haemost. Suppl 1:188-195, 2007
• Boulesteix A.-L., Strobl C., Weidinger S., Wichmann H.-E., Wagenpfeil S.: "Multiple testing for SNP-SNP interactions". Statistical Applications in Genetics and Molecular Biology: Vol. 6 : Iss. 1, Article 37, 2007
• Kreuzer G., Daumer M.: "Machbarkeitsstudie zur Aktivitätsüberwachung von Astronauten unter partieller Gravitation mit einem 3D-Accelerometer – actibelt®." In: Fortschritt-Berichte VDI. Reihe 17 Biotechnik/Medizintechnik, Band Nr.: 267 "Automatisierungstechnische Verfahren für die Medizin 7. Workshop Tagungsband" (ISBN: 978-3-18-326717-0), Tita R., Riener R., Buss M., Lüth T.C. (Eds.), 2007
• Daumer M, Scholz M, Boulesteix AL, Pildner von Steinburg S, Schiermeier S, Hatzmann W, Schneider KTM: "The Normal Fetal Heart Rate Study: Analysis Plan", Available from Nature Precedings, 2007
• Samani NJ et al. for the WTCCC and the Cardiogenics Consortium: "Genomewide Association Analyses of Coronary Artery Disease". N Engl J Med 357, 443-453, 2007
• Daumer M., Held U., Ickstadt K., Heinz M., Schach S., and Ebers G.: "Reducing the Probability of False Positive Research Findings by Pre-Publication Validation - Experience with a Large Multiple Sclerosis Database." Available from Nature Precedings, 2007
• Daumer M., Neuhaus A., Lederer C., Scholz M., Wolinsky JS and Heiderhoff M.: "Prognosis of the individual course of disease - steps in developing a decision support tool for Multiple Sclerosis." BMC Medical Informatics and Decision Making 2007, 7:11
• Boulesteix AL: "WilcoxCV: an R package for fast variable selection in cross-validation." Bioinformatics, 2007, May 11
• Schach S., Scholz M., Wolinsky J., Kappos L.: "Pooled historical MRI data as a basis for research in multiple sclerosis – A statistical evaluation." Multiple Sclerosis 13 (4): 509-516, 2007
• Daumer M, Thaler K, Kruis E, Feneberg W, Staude G, Scholz M: "Steps towards a miniaturized, robust and autonomous measurement device for the long-term monitoring of the activity of patients – ActiBelt". Biomedizinische Technik/Biomedical Engineering 52, p. 149–155, 2007
• Tremlett H, Seemüller S, Zhao Y, Yoshida EM, Oger J, Petkau J: "Liver test abnormalities in multiple sclerosis: findings from placebo treated patients." Neurology 67, p. 1291-1294, 2006
• Young PJ, Lederer C, Eder K, Daumer M, Neiss A, Polman C, Kappos L, for the Sylvia Lawry Centre: "Relapses and subsequent worsening of disability in relapsing remitting Multiple Sclerosis." Neurology 67: 804-808, 2006
• Then Bergh F, Kumpfel T, Schumann E, Held U, Schwan M, Blazevic M, Wismuller A, Holsboer F, Yassouridis A, Uhr M, Weber F, Daumer M, Trenkwalder C and Auer DP: "Monthly i.v. methylprednisolone in relapsing-remitting MS - Reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations". BMC Neurology 6:19, 2006
• Daumer M, Duerr D, Goldstein S, Maudlin T, Tumulka R, Zanghi N. The message of the Quantum? Quantum Physics, April 2006
• Li DKB, Held U, Petkau J, Daumer M, Barkhof F, Fazekas F, Frank JA, Kappos L, Miller DH, Simon JH, Wolinsky JS, Filippi M, for the Sylvia Lawry Centre for MS Research. "MRI T2 Lesion Burden in Multiple Sclerosis: A Plateauing Relationship with Clinical Disability". Neurology 66, p. 1384-1389, 2006
• Daumer M., Griffith L., Meister W., Nash A, Wolinsky J.: "Survival, and time to an advanced disease state or progression, of untreated patients with moderately severe MS in a multicenter observational database - Relevance for design of a clinical trial for high dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation." Multiple Sclerosis 12 (Vol. 2), p.174-179, 2006
• Held U., Heigenhauser L., Shang C., Kappos L., Polman C.: "Predictors of relapse rate in MS clinical trials", Neurology 65: p. 1769-1773, 2005
• Barkhof F., Held U., Simon JH, Daumer M., Fazekas F., Filippi M., Frank JA, Kappos L., Li D., Menzler S., Miller DH, Petkau J., Wolinsky J.: "Predicting gadolinium-enhancement status in MS patients eligible for randomized clinical trials", Neurology 65, p.1447-1454, 2005
• Flachenecker P., Zettl U.K., Götze U., Haas J., Schimrigk S., Elias W., Pette M., Eulitz M., Hennig M., Bertram J., Hollweck R., Neiss A., Daumer M., Pitschnau-Michel D., Rieckmann P.: "MS-Register in Deutschland: 1. Design und erste Ergebnisse der Pilotphase". Der Nervenarzt 76, p. 967 - 975, 2005
• Baumhackl U., Kappos L., Radue E.W., Freitag P., Guseo A., Daumer M., Mertin J.: "A randomised, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis". Multiple Sclerosis 11: p. 166-168, 2005
• Noseworthy J., Kappos L., Daumer M.: "Competing interests in multiple sclerosis research" Lancet 361, 9354:350-351, 2003
• Imkeller P., Lederer C.: The cohomology of stochastic and random differential equations, and local linearization of stochastic flows. Stoch. Dyn. 2, No.2, p. 131-159, 2002

Abstracts

• Schoene C.: "Hidden-Markov-Modell und Autokorrelationsfunktion zur Bewegungs- und Gangklassi?kation dreidimensionaler Beschleunigungsdaten", Diploma Thesis, 2008
• Slawski M., Boulesteix AL., Daumer M.: "’CMA’ - Steps in developing a comprehensive R-toolbox for classification with microarray data and other high-dimensional problems." First Conference of the Central European Network - 54. Biometrisches Kolloquium. Lifestat 2008, LMU Munich, 10.-13.03.2008
• Neuhaus A., Augustin T., Heumann C., Daumer M.: "A Review on Joint Models in Biometrical Research." First Conference of the Central European Network - 54. Biometrisches Kolloquium. Lifestat 2008, LMU Munich, 10.-13.03.2008
• Lederer C., Tang D., Otten S., Pohlmann H., Strobl R., Pinheiro J., Karlsson G., Kappos L., Aradhye S.: "Identifying historical controls for MS follow-up studies in a large database – Methodological considerations". ECTRIMS 2007, Prague, 11.-14. Oct. 2007
• Tintoré M., Hagstromer M., Wicklein EM., Daumer M., Penner IK., Sjostrom M.: "The BEGIN Study: Assessment of physical activity, fatigue and health-related quality of life in the early stages of multiple sclerosis". ECTRIMS 2007, Prague, 11.-14. Oct. 2007
• Neuhaus A., Güntner M., Morrissey SP.: "T2 lesion volume surrogacy validation in patients with a clinically isolated syndrome". ECTRIMS 2007, Prague, 11.-14. Oct. 2007
• Neuhaus A., Güntner M., Morrissey SP.: "Risk factors for conversion to multiple sclerosis in patients with a clinically isolated syndrome". ECTRIMS 2007, Prague, 11.-14. Oct. 2007
• Gärtner J., Stark W., Brück W., Tardieu M., Mikaeloff Y., Harner N., Otten S., Daumer M., Neuteboom R., Hintzen R.: "European Pediatric MS Cohorts: Validation of the French COMSIS severity score in the German and Dutch cohorts". ECTRIMS 2007, Prague, 11.-14. Oct. 2007
• Harner N., Thaler K., Daumer M.: "Concept and first results for an individualized calibration of movement detection". BMT 2007, Aachen, 26.-29. Sept. To appear in Biomedizinische Technik/Biomedical Engineering, 2007
• Rashid A., Schlüfter F., Holtmann C., Daumer M., Thaler K., Schlesinger S.: "Einsatz von Beschleunigungssensoren zum Aktivitätsmonitoring von Multiple Sklerose Patienten im Home Care Bereich". BMT 2007, Aachen, 26.-29. Sept. To appear in Biomedizinische Technik/Biomedical Engineering, 2007
• Daumer M., Held U., Ickstadt K., Heinz M., Schach S., and Ebers G.: "The database of the Sylvia Lawry Centre for MS Research". EFNS 2007, Brussels, 25.-28. Aug. 2007
• Hagstromer M., Sjostrom M., Wicklein EM., Daumer M., Penner IK., Tintoré M.: "The BEGIN Study: Assessment of physical activity, fatigue and health-related quality of life in the early stages of multiple sclerosis". EFNS 2007, Brussels, 25.-28. Aug. 2007
• Daumer M.: "Predictive factors in placebo and natural history data." Multiple Sclerosis 12, Suppl. 1, S.18, 2006
• Daumer M., Thaler K., Goßner T., Kruis E., Staude G., Feneberg W., Scholz M.: "ActiBelt: A portable, belt-buckle accelerometer to monitor mobility in multiple sclerosis." Multiple Sclerosis 12, Suppl. 1, 2006
• Daumer M., Hapfelmeier A., Neuhaus A., Ebers G.: "The additional predictive value of Magnetic Resonance Imaging for the prediction of future relapses if relapse history is available." Multiple Sclerosis 12, Suppl. 1, S.46-S.47, 2006
• Daumer M.: "Monitoring and characterising human gait and activity with a mobile accelerator device – ActiBelt." GMDS 2006, 10. - 14. September 2006, Leipzig
• Held U., Daumer M., Scholz M., Heinz M., Schach S.: "Validation procedure of the SLCMSR: methodological and practical aspects." International Biometric Conference, Montreal, Canada, 16-21 July 2006
• Daumer M., Thaler K., Kruis E., Feneberg W., Staude G., Scholz M.: "Steps towards a miniaturized, robust and autonomous measurement device for the long-term monitoring of the activity of patients – ActiBelt". Biosignalverarbeitung, 13.-14.07.2006, University Potsdam
• Thaler K., Daumer M.: Steps towards an individual step pattern from three-dimensional accelerations". Workshop Biosignalverarbeitung, 13.-14.07.2006, University Potsdam
• Neuhaus A., Daumer M., O’Connor P.: "Comparing several simple models to predict the development of disability in individual Multiple Sclerosis (MS) patients from their disability history". 16th Meeting of the European Neurological Society (ENS), May 27-31, 2006, Lausanne Switzerland
• Noyes K., Daumer M., Dick A., Dorsey R., Holloway R., McCabe C., Miller D., Schwid S., Shih HC.: “Comparing apples with what: Different inputs and assumptions produce different conclusions in MS economic models.” 11th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research. May 22, 2006, Philadelphia, PA.
• Noyes K., Daumer M., Dick A., Dorsey R., Holloway R., McCabe C., Miller D., Schwid S., Shih HC.: “Comparing Cost-Effectiveness Models for MS Disease-Modifying Agents: Different Inputs and Assumptions Produce Different Conclusions.” 58th Annual Meeting of the American Academy of Neurology, April 5, 2006, San Diego, CA
• Ebers G., Heigenhauser L., Daumer M., Lederer C., Noseworthy J.: "The measurement of disability." Multiple Sclerosis 11, Suppl. 1, 2005
• Neuhaus A., Seemüller S.: "Can results from clinical trials be generalised to patients in daily practice?", Multiple Sclerosis 11, Suppl. 1, 2005
• Mair B., Held U., Kappos L., Wolinsky J.S., Daumer M., Held L.: "Longitudinal changes in T2 lesion volume in multiple sclerosis: possible restricted utility as a clinical trial outcome". Journal of Neurology 252, Suppl 2, p.22, June 2005
• Di Serio C.: "Clinical aspects of MS. Generating a virtual MS placebo patient: an exponential mixed effects model with autoregressive components - EMEAR(1). ECTRIMS, Vienna, Austria, Oct 2004 Multiple Sclerosis
• Held U., Barkhof F., Petkau J., Daumer M., Simon J., Kappos L.: "Prediction of gadolinium enhancement status on MRI at baseline of multiple sclerosis trials". Aktuelle Neurologie 31, S1, Oct 2004, p. 8.
• Neuhaus A., Daumer M., Kappos L., Augustin T., Küchenhoff H.: "Modelling time to progression in multiple sclerosis regarding the error in the response variable". Multiple Sclerosis, Vol 10, Suppl 2, Sept. 2004, p. 99
• Graml A., Held U., Kappos L., Daumer M.: "Comparison of Approaches for Sample Size Calculations in MS Trials Using Gadolinium Enhanced New Lesion Counts in Frequent Magnetic Resonance Imaging as Primary Outcome". Multiple Sclerosis, Vol 10, Suppl 2, Sept. 2004, p. 273
• Neuhaus A., Augustin T., Daumer M., Kappos L., Kuechenhoff H., Polman C.: "Modelling Time to Progression in Multple Sclerosis"; Biometrical Journal, , Vol 46 (suppl.), p 149; Mar 2004
• Held U., Li DKB, Barkhof F., Petkau J.: "Bayesian prediction of the number of lesions in mulple sclerosis trials"; Biometrical Journal, , Vol 46 (suppl.), p 27; Mar 2004
• Eder K., Menzler S., Held U., Daumer M., Küchenhoff H., Neiß A.: "Alternative Designs for Phase II MS trials"; Biometrical Journal, , Vol 46 (suppl.), p 53; Mar 2004
• Young P., Kappos L., Daumer M.: "Assessing different criteria for determining sustained progression of EDSS in relapsing-remitting multiple sclerosis patients in clinical trials"; Multiple Sclerosis, Vol. 9,1, p111; Sep 2003
• Daumer M., Kessner S., Lederer C., Neiss A.: "Modelling placebo groups for clinical trials"; Multiple Sclerosis, Vol. 9,1, p 41; Sep 2003
• Barkhof F., Simon J., Daumer M., Held U., Menzler S., Petkau J., Miller D.: "Predicting the occurence of enhancement in randomised clinical trials of multiple sclerosis"; Multiple Sclerosis, Vol. 9,1, p111- 112, Sep 2003
• Li DKB, Filippi M., Petkau J., Held U., Daumer M.: "T2 Lesion Burden on MRI Plateaus as MS Disability Accumulates"; Multiple Sclerosis, Vol. 9,1, p 58, Sep 2003

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Reports, Discussion Papers, Diploma Theses

• Schoene C.: "Hidden-Markov-Modell und Autokorrelationsfunktion zur Bewegungs- und Gangklassifikation dreidimensionaler Beschleunigungsdaten", Diploma Thesis, 2008
• Lachmann L.: "Multiple Sklerose und Bewegung - eine Studie zur Aktivitätsmessung mittels Akzelerometrie", Diploma Thesis, 2007
• Gnatowski E.: "Stability of methods for the analysis of differential gene expression", Diploma Thesis, 2007
• Porzelius C.: "Microarray-based prediction with emphasis on clinical parameters", Diploma Thesis, 2007
• Neuhaus A., Augustin T., Heumann C., Daumer M.: "A Review on Joint Models in Biometrical Research". Discussion Paper 506 of the "Sonderforschungsbereich 386" of the DFG; 2007
• Bayer F.: "Mathematische Aspekte der nichtlinearen intensitaetsbasierten Bildregistrierung", Diploma Thesis, 2007
• Gossner Th.: "Experiments and Validation of a Three-Dimensional Accelerometer in a Belt Buckle – ActiBelt – for Continuous Multiple Sclerosis Patient Monitoring", Diploma Thesis, 2007
• Harner N.: "Modellierung von Verweildauern für Patienten mit Multipler Sklerose (MS)", Master Thesis, 2007
• Guentner M.: "Predicting the Natural History of Multiple Sclerosis in Patients seen from Disease Onset", Diploma Thesis, 2006
• Thaler K.: "Akquisition, Vorverarbeitung und Analyse von hochaufgelosten, dreidimensionalen Beschleunigungsdaten zur Aktivitätsbestimmung bei MS-Patienten", Diploma Thesis, 2006
• The European Medicines Agency's Need for Revision of the Note for Guidance on Clinical Investigation of Medicinal Products for the Treatment of Multiple Sclerosis (CPMP/EWP/561/98). Comments Provided From: The Sylvia Lawry Centre for Multiple Sclerosis Research (Munich, Germany), February 21, 2005
• Heinz M: "Validation Processes of Results in Biomedical Research Centres", Diploma Thesis, 2005
• De Souza: "Weiterentwicklung einer internetbasierten Plattform für Risikoassessment bei MS", Diploma-Thesis, 2005
• Mair B: "Longitudinale Modellansätze zur Prädiktion von MRI Parametern bei MS", Diploma Thesis, 2005
• Schach S., Daumer M., Neiß A.: "Maintaining high quality of statistical evaluations based on the SLCMSR data base." Validation Policy of the Sylvia Lawry Centre. 2005
• Heigenhauser, L., Confavreux, C., Daumer, M., Ebers, G., Kappos, L., Lederer, C., Neiß, A., Polman, C., Vukusic, S., Hellriegel, B.: "Treating Systematic Errors in Multiple Sclerosis Data." Discussion Paper 435 of the "Sonderforschungsbereich 386" of the DFG; 2005
• Held, U., Heigenhauser, L., Shang, C., Kappos, L., Polman, C.: "Predicting the On-Study Relapse Rate for Multiple Sclerosis Patients in Clinical Trials. Discussion Paper 430 of the "Sonderforschungsbereich 386" of the DFG; 2005
• Ebers,G. C., Heigenhauser, L., Daumer, M., Lederer, C. and Noseworthy, J. H.: "Multiple sclerosis, the measurement of disability and access to clinical trial data." Discussion Paper 429 of the "Sonderforschungsbereich 386" of the DFG; 2005
• Graml A.: Sample size calculation for Phase II MS trials with magnetic resonance imaging based outcome variables, Diploma Thesis, 2004
• Di Serio C.: An exponential mixed effect model with autocorrelation (EMEAR[1]) for addressing multiple sclerosis clinical prediction, Technical Report, 2004
• Neuhaus A.: "Modelling Time to Progression in Multiple Sclerosis"; Diploma Thesis; 2004
• Hellriegel B., Daumer M., Neiß A.: "Analysing the course of multiple sclerosis with segmented regression models"; Discussion Paper of the "Sonderforschungsbereich 386" of the DFG; 2003
• Gehrmann U., Hellriegel B., Neiss, A., Fahrmeir, L.: "Analysis of the time to sustained progression in Multiple Sclerosis using generalised linear and additive models." Discussion Paper 354 of the "Sonderforschungsbereich 386" of the DFG; 2003
• Gehrmann U.: "Analysis of the Disease Course of MS with Survival Models", Diploma Thesis, 2003
• Di Serio C., Lamina C.: "Bayesian P-Splines to Investigate the Impact of Covariates on Multiple Sclerosis Clinical Course"; Discussion Paper 353 of the "Sonderforschungsbereich 386" of the DFG; 2003
• Eder K.: "Alternative Designs in Phase II MS-Studies"; Diploma Thesis; 2003
• Burkhardt: "A Markov Chain Monte Carlo Algorithm for the Segmentation of T1-MR-Images of the Head", Diploma Thesis, 2002
• Lamina C.: "Modelling the Disease Course of MS with Mixed Effects", Diploma Thesis, 2002

Seminars

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